Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70-75.
Function
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
This protein also forms one of the three subunits of the IL-15 receptor.
Activation of the receptor increases proliferation of CD8 effector T cells.
Interactions
IL2RB has been shown to interact with:
- CISH,
- HGS,
- Janus kinase 1, and
- SHC1.
See also
- IL-2 receptor
- IL-15 receptor
References
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
